Factors influencing drug deposition in the nasal cavity upon delivery via nasal sprays

nasal drug delivery in traditional persian medicine

discussion while this novel type of drug delivery is known as a suitable substitute for oral and parenteral administration, it was well accepted and extensively mentioned in persian medical and pharmaceutical manuscripts and other traditional systems of medicine as well. accordingly, medieval pharmaceutical standpoints on nasal dosage forms could still be an interesting subject of study. theref...

Smart Polymers in Nasal Drug Delivery

Nasal drug delivery has now been recognized as a promising route for drug delivery due to its capability of transporting a drug to systemic circulation and central nervous system. Though nasal mucosa offers improved bioavailability and quick onset of action of the drug, main disadvantage associated with nasal drug delivery is mucocilliary clearance due to which drug particles get cleared from t...

Nasal Drug Delivery in Traditional Persian Medicine

BACKGROUND Over one hundred different pharmaceutical dosage forms have been recorded in literatures of Traditional Persian Medicine among which nasal forms are considerable. OBJECTIVES This study designed to derive the most often applied nasal dosage forms together with those brief clinical administrations. MATERIALS AND METHODS In the current study remaining pharmaceutical manuscripts of P...

Unsteady Particle Deposition in a Human Nasal Cavity

The deposition efficiency of unsteady inhalation is investigated in present study by using computational fluid dynamics techniques. Comparison with steady inhalation is also discussed. The inspiratory cycle of a realistic unsteady inhalation profile was applied at the outlet of nasopharynx, which has the maximum flow rate of 40.3L/min. Aerodynamic particle sizes of 5μm and 20μm were studied in ...

Stone in the Nasal Cavity